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Phentermine hydrochloride capsules 15 mg /day (1.5–3.0 mg/L) in 20 subjects aged 18–51, for at least 7 consecutive days. The study was approved by Ethics Committee of Aarhus University Hospital, Aarhus, Denmark, where the study was conducted. control group given placebo. Subjects were randomly assigned to take 1-mg/day (n = 18), 3-mg/day 2) or 5-mg/day (n = 14). The placebo group received same placebo. The study was not powered to determine if any differences in outcome between the treatment groups were detected, because we did not investigate the effects of these drugs on any other health outcome. All subjects provided written, informed consent, which was obtained from their attending physician or ethics committee. The primary outcome was clinical assessment score (SAS-Cog) for adverse events during the first 3 months of treatment. Secondary and exploratory outcomes included the clinical assessment score at 30 days, which was the primary outcome measure in this study; patient's clinical evaluation for the use of prescribed therapy and general medical disorder; patient's overall treatment adherence, which was scored on a 7-point scale; and patient-reported side effects. The primary end point was clinical assessment score (SAS-Cog) before the first treatment day. Secondary and exploratory outcomes included: adherence to medication; medical treatment for all-cause and specific illness symptoms; patient-reported side effects. The effects were assessed at beginning and the end of each drug intervention phase. Outcome measures were the primary (SAS-Cog) in both dose regimens. Secondary and exploratory outcomes included: changes in patient ratings of perceived benefit and adverse events with the selected dose, adherence and adherence-related medical treatment; patient-reported side effects. Evaluate all patients who received ≥ 4 tablets of a single drug (ie, the dose of medication being prescribed) during an intervention phase. this first 3-month phase, the study did not involve any discontinuation to rearm patients or evaluate the tolerability of drug or its treatment regimen. All patients received a single tablet of study drug every day during the first 3 months of study. The study was a randomized, double-blind, placebo-controlled, parallel-group study. One tablet of each active drug and placebo tablet (containing phentermine hydrochloride capsules and matching placebo tablets) was administered in 3 daily doses as a single administration. This study used two active drug regimens: 1) a randomized 3-week open-label dose-escalation phase that resulted in an increase of 500 μg dose (0.625 mg/0.015 mg/g) of placebo and tablets; 2) a randomized 3-week double-blind pharmacological maintenance phase that consisted of a dose-escalation phase that increased 250 μg of dose (0.625 mg/0.015 mg/g) phentermine, a 300 μg of dosage placebo and tablets daily, or no treatment in the following 3 weeks. All participants were recruited through newspaper advertisements, flyers on college campuses, campus newspapers and through the Internet. Individuals with a diagnosis of ADHD, oppositional defiant disorder (ODD), conduct (CD) where to buy phentermine 37.5 online or with hyperactivity (CDH) were excluded, as women taking oral contraceptives or those who had taken amphetamines in the past 90 days. Eighty-eight percent of the initial cohort was female. sample had a mean age of 18.9 years (range 12–42 years), and 40% were African-American, 26% Caucasian, 10% Asian and 6% were other.

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